陈情。，王华庆 ，朱晓琳 ，周玉文 ，张鹏      天津医科大学学报

[摘要】目的：探讨表阿霉素心脏毒性的临床量化指标。方法：对60例含表阿霉素化疗的恶性肿瘤病人采用化疗
前、化疗中、化疗后监测心电图、心肌酶和超声心动的方法分析表阿霉素在正常心脏和异常心脏的耐量情况。结果：
心脏毒性组与正常对照组的心脏毒性和累积有显著性不同。结论：表阿霉素用量与心脏状况密切相关；心脏病人的
表阿霉素用量不宜超过600 mg／m2，同时应适当加用心脏保护剂。
[关键词】表阿霉素；心脏毒性；累积量
[中图分类号】R541．9 [文献标识码】A [文章编号】1006—8147(2004)03—0376—03
M ultiple。。factor evaluation of the cardiac toxicity of epirubicin
CHEN Qing ，WANG Hua—qing2，ZHU Xiao—lin3，ZHOU Yu—wen ，ZHANG Peng1
(Cancer Hospital of Tianjin Medical Univercity，Tianjin 300060，China)
ABSTRACT Objective：To study the clinical limited accumulation of epirubicin．Methods：A
controlled study of 60 malignant tumor cases on ECG，myocardial enzyme and left ventricular
ejection fraction in the chemotherapy was carried out．Results：The occurrance rate of cardiac
toxicity and limited accumulatation were significant different between cardiopathy group and
normal group．Conclusion：The limited accumulation of epirubicin is associated with cardiac
function and should not more than 600 mg／m2 when it can be used in the malignant tumor with
cardiopathy．
KEY WORDS Epirubicin；Cardiac toxicity；Limited accumulation of epirubicin